Cardiovascular Collapse, Progressive Lactic Acidosis, Pulmonary Hypertension and Polyuria: Think Thiamine Deficiency!
نویسندگان
چکیده
Shock is a pathological condition characterized by imbalance between oxygen demand and supply. Irrespective of the cause, shock leads to state energy failure due decrease in adenosine triphosphate (ATP) production, creation lactic acidosis, as consequence, multiple organ dysfunction [1].
منابع مشابه
Reversible lactic acidosis in a newborn with thiamine transporter-2 deficiency.
Thiamine transporter-2 deficiency is a recessive disease caused by mutations in the SLC19A3 gene. Patients manifest acute episodes of encephalopathy; symmetric lesions in the cortex, basal ganglia, thalami or periaqueductal gray matter, and a dramatic response to biotin or thiamine. We report a 30-day-old patient with mutations in the SLC19A3 gene who presented with acute encephalopathy and inc...
متن کاملType B lactic acidosis secondary to thiamine deficiency in a child with malignancy.
Type B lactic acidosis is an underrecognized clinical entity that must be distinguished from type A (hypoxic) lactic acidosis. We present the case of a 4-year-old boy with medulloblastoma who presented with lactic acidosis in the setting of septic shock. His hyperlactatemia persisted to high levels even after his hemodynamic status improved. After administration of intravenous thiamine, his lac...
متن کاملThiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient
Thiamine plays a critical role in energy metabolism. Critically ill children and adults may develop thiamine deficiency with ultimately increased mortality due to potentially irreversible consequences of severe type B lactic acidosis. We report a case of an unvaccinated term neonate with malignant pertussis requiring extracorporeal membrane oxygenation and continuous renal replacement therapy, ...
متن کاملReversible Lactic Acidosis in a Newborn With Thiamine Transporter-2 Deficiency abstract
Thiamine transporter-2 deficiency is a recessive disease caused by mutations in the SLC19A3 gene. Patients manifest acute episodes of encephalopathy; symmetric lesions in the cortex, basal ganglia, thalami or periaqueductal gray matter, and a dramatic response to biotin or thiamine. We report a 30-day-old patient with mutations in the SLC19A3 gene who presented with acute encephalopathy and inc...
متن کاملSevere lactic acidosis reversed by thiamine within 24 hours
iamine is a water-soluble vitamin that plays a pivotal role in carbohydrate metabolism. In acute defi ciency, pyruvate accumulates and is metabolized to lactate, and chronic defi ciency may cause polyneuropathy and Wernicke encephalopathy. Classic symptoms include mental status change, ophthalmoplegia, and ataxia but are present in only a few patients [1]. Critically ill patients are prone to t...
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ژورنال
عنوان ژورنال: International journal of critical care and emergency medicine
سال: 2022
ISSN: ['2474-3674']
DOI: https://doi.org/10.23937/2474-3674/1510141